Assay Detail
Functional
CHEMBL3583703
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Cytotoxicity against human SNU638 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-638 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Activity Relationships of Neplanocin A Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.62 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.52 |
| CHEMBL8771 | NEOPLANOCIN A | — | 1 | 6.16 |
| CHEMBL154745 | — | — | 1 | 6.04 |
| CHEMBL3580896 | — | — | 1 | 6.02 |
| CHEMBL200935 | DEAZANEPLANOCIN A | — | 1 | 5.92 |
| CHEMBL64718 | FLUORO-NEPLANOCIN A | — | 1 | 5.66 |
| CHEMBL310547 | — | — | 1 | 5.64 |
| CHEMBL3580900 | — | — | 1 | 5.43 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.40 |
| CHEMBL80375 | — | — | 1 | 4.55 |
| CHEMBL3580899 | — | — | 1 | 4.52 |
| CHEMBL3580894 | — | — | 1 | - |
| CHEMBL3580895 | — | — | 1 | - |
| CHEMBL3580897 | — | — | 1 | - |
| CHEMBL3580898 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL8771 | NEOPLANOCIN A | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL154745 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL3580896 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL200935 | DEAZANEPLANOCIN A | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL64718 | FLUORO-NEPLANOCIN A | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL310547 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL3580900 | — | IC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL803 | CYTARABINE | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL80375 | — | IC50 | = | 28160.0 | nM | 4.55 |
| CHEMBL3580899 | — | IC50 | = | 30190.0 | nM | 4.52 |
| CHEMBL3580894 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3580895 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3580897 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3580898 | — | IC50 | > | 100000.0 | nM | - |