Assay Detail
Functional
CHEMBL3583705
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse TAAR1 expressed in HEK293 cells coexpressing cAMP BRET biosensor assessed as induction of CAMP production after 20 mins by bioluminescence resonance energy transfer assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.29 | 6.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL610 | PHENETHYLAMINE | — | 1 | 6.86 |
| CHEMBL1182312 | — | — | 1 | 6.72 |
| CHEMBL3580902 | — | — | 1 | 6.62 |
| CHEMBL3580905 | — | — | 1 | 6.10 |
| CHEMBL3580901 | — | — | 1 | 5.77 |
| CHEMBL3580906 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL610 | PHENETHYLAMINE | EC50 | = | 138.0 | nM | 6.86 |
| CHEMBL1182312 | — | EC50 | = | 189.0 | nM | 6.72 |
| CHEMBL3580902 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3580905 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3580901 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3580906 | — | EC50 | = | 2200.0 | nM | 5.66 |