Assay Detail
Binding
CHEMBL3583992
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Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO-K1 cell membrane by competitive displacement assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel azoles as potent and selective cannabinoid CB2 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.84 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408430 | — | — | 1 | 7.66 |
| CHEMBL3581222 | — | — | 1 | 7.53 |
| CHEMBL3581226 | — | — | 1 | 7.30 |
| CHEMBL3581228 | — | — | 1 | 7.29 |
| CHEMBL3581225 | — | — | 1 | 7.11 |
| CHEMBL3581220 | — | — | 1 | 7.09 |
| CHEMBL3581229 | — | — | 1 | 6.90 |
| CHEMBL3581224 | — | — | 1 | 6.84 |
| CHEMBL3581227 | — | — | 1 | 6.75 |
| CHEMBL3581223 | — | — | 1 | 5.57 |
| CHEMBL3581221 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408430 | — | Ki | = | 21.8 | nM | 7.66 |
| CHEMBL3581222 | — | Ki | = | 29.4 | nM | 7.53 |
| CHEMBL3581226 | — | Ki | = | 49.7 | nM | 7.30 |
| CHEMBL3581228 | — | Ki | = | 51.6 | nM | 7.29 |
| CHEMBL3581225 | — | Ki | = | 77.4 | nM | 7.11 |
| CHEMBL3581220 | — | Ki | = | 81.7 | nM | 7.09 |
| CHEMBL3581229 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL3581224 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL3581227 | — | Ki | = | 177.0 | nM | 6.75 |
| CHEMBL3581223 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL3581221 | — | Ki | = | 6237.0 | nM | 5.21 |