Assay Detail
Functional
CHEMBL3583995
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Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel azoles as potent and selective cannabinoid CB2 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.38 | 7.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408430 | — | — | 1 | 7.79 |
| CHEMBL3581226 | — | — | 1 | 7.40 |
| CHEMBL3581222 | — | — | 1 | 7.38 |
| CHEMBL3581228 | — | — | 1 | 7.36 |
| CHEMBL3581220 | — | — | 1 | 7.23 |
| CHEMBL3581225 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408430 | — | EC50 | = | 16.4 | nM | 7.79 |
| CHEMBL3581226 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3581222 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3581228 | — | EC50 | = | 43.6 | nM | 7.36 |
| CHEMBL3581220 | — | EC50 | = | 59.1 | nM | 7.23 |
| CHEMBL3581225 | — | EC50 | = | 72.0 | nM | 7.14 |