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Assay Detail

CHEMBL3584167

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV1 NL4.3-Ren infected in human MT2 cells assessed as inhibition of viral growth measured 48 hrs post infection by luminometry
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT2
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Isolation, Structural Modification, and HIV Inhibition of Pentacyclic Lupane-Type Triterpenoids from Cassine xylocarpa and Maytenus cuzcoina.
Callies O, Bedoya LM, Beltrán M, Muñoz A, Calderón PO, Osorio AA, Jiménez IA, Alcamí J, Bazzocchi IL.
J Nat Prod (2015) 78 : 1045 -1055
PubMed 25927586 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.23 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL404519 BEVIRIMAT 2.0 1 8.00
CHEMBL3581943 1 5.85
CHEMBL3581947 1 5.77
CHEMBL469284 BETULONE 1 5.39
CHEMBL297478 BETULONAL 1 5.38
CHEMBL3581946 1 5.16
CHEMBL3581944 1 5.16
CHEMBL3581941 1 5.10
CHEMBL3581945 1 5.06
CHEMBL140040 3-EPI-BETULIN 1 5.06
CHEMBL3581940 1 5.02
CHEMBL511283 NEPETICIN 1 4.98
CHEMBL3581948 1 4.88
CHEMBL1079568 1 4.87
CHEMBL470447 GLOCHIDIOL 1 4.86
CHEMBL512065 OCHRACEOLIDE A 1 4.41
CHEMBL3581942 1 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL404519 BEVIRIMAT IC50 = 10.0 nM 8.00
CHEMBL3581943 IC50 = 1400.0 nM 5.85
CHEMBL3581947 IC50 = 1700.0 nM 5.77
CHEMBL469284 BETULONE IC50 = 4100.0 nM 5.39
CHEMBL297478 BETULONAL IC50 = 4200.0 nM 5.38
CHEMBL3581946 IC50 = 6900.0 nM 5.16
CHEMBL3581944 IC50 = 7000.0 nM 5.16
CHEMBL3581941 IC50 = 7900.0 nM 5.10
CHEMBL3581945 IC50 = 8700.0 nM 5.06
CHEMBL140040 3-EPI-BETULIN IC50 = 8800.0 nM 5.06
CHEMBL3581940 IC50 = 9500.0 nM 5.02
CHEMBL511283 NEPETICIN IC50 = 10400.0 nM 4.98
CHEMBL3581948 IC50 = 13100.0 nM 4.88
CHEMBL1079568 IC50 = 13400.0 nM 4.87
CHEMBL470447 GLOCHIDIOL IC50 = 13900.0 nM 4.86
CHEMBL512065 OCHRACEOLIDE A IC50 = 39000.0 nM 4.41
CHEMBL3581942 IC50 = 100000.0 nM 4.00