Assay Detail
Functional
CHEMBL3584412
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Anti-inflammatory activity in mouse RAW264.7 cells assessed as LPS-stimulated inhibition of nitric oxide production incubated simultaneously with LPS for 24 hrs by Griess reagent based assay
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ervatamines A-I, Anti-inflammatory Monoterpenoid Indole Alkaloids with Diverse Skeletons from Ervatamia hainanensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 12 | - | - |
| IC50 | 3 | 4.45 | 4.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364613 | CORONARIDINE | — | 1 | 4.59 |
| CHEMBL3580947 | — | — | 1 | 4.38 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 4.37 |
| CHEMBL3580944 | — | — | 1 | - |
| CHEMBL3580943 | — | — | 1 | - |
| CHEMBL3580942 | — | — | 1 | - |
| CHEMBL4524091 | — | — | 1 | - |
| CHEMBL3580940 | — | — | 1 | - |
| CHEMBL3580939 | — | — | 1 | - |
| CHEMBL3580938 | — | — | 1 | - |
| CHEMBL3580937 | — | — | 1 | - |
| CHEMBL3580936 | — | — | 1 | - |
| CHEMBL461609 | HEYNEANINE | — | 1 | - |
| CHEMBL3580945 | — | — | 1 | - |
| CHEMBL3580946 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364613 | CORONARIDINE | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL3580947 | — | IC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 42600.0 | nM | 4.37 |
| CHEMBL3580944 | — | Inhibition | - | % | - | |
| CHEMBL3580943 | — | Inhibition | - | % | - | |
| CHEMBL3580942 | — | Inhibition | - | % | - | |
| CHEMBL4524091 | — | Inhibition | - | % | - | |
| CHEMBL3580940 | — | Inhibition | - | % | - | |
| CHEMBL3580939 | — | Inhibition | - | % | - | |
| CHEMBL3580938 | — | Inhibition | - | % | - | |
| CHEMBL3580937 | — | Inhibition | - | % | - | |
| CHEMBL3580936 | — | Inhibition | - | % | - | |
| CHEMBL461609 | HEYNEANINE | Inhibition | - | % | - | |
| CHEMBL3580945 | — | Inhibition | - | % | - | |
| CHEMBL3580946 | — | Inhibition | - | % | - |