Assay Detail
Binding
CHEMBL3584583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Modulation of MRP1 (unknown origin) transfected in human 2008/MRP1 cells assessed as potentiation of doxorubicin-induced cytotoxicity measured as doxorubicin IC50 at 1 uM after 5 days by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | 2008/MRP1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Multidrug resistance-associated protein 1 (CHEMBL3004) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.59 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3582167 | — | — | 1 | 6.85 |
| CHEMBL3582168 | — | — | 1 | 6.85 |
| CHEMBL3582149 | — | — | 1 | 6.49 |
| CHEMBL3582156 | — | — | 1 | 6.38 |
| CHEMBL3582155 | — | — | 1 | 6.36 |
| CHEMBL488910 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3582167 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL3582168 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL3582149 | — | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL3582156 | — | IC50 | = | 418.0 | nM | 6.38 |
| CHEMBL3582155 | — | IC50 | = | 434.0 | nM | 6.36 |
| CHEMBL488910 | — | IC50 | - | — | - |