Assay Detail
Functional
CHEMBL3584881
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 cultured in human erythrocytes incubated for 48 hrs by [3H]-hypoxanthine incorporation assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.14 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3581500 | — | — | 1 | 9.15 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 9.00 |
| CHEMBL3581498 | — | — | 1 | 8.85 |
| CHEMBL3581479 | — | — | 1 | 8.72 |
| CHEMBL3581502 | — | — | 1 | 8.70 |
| CHEMBL3581499 | — | — | 1 | 8.60 |
| CHEMBL3581503 | — | — | 1 | 8.54 |
| CHEMBL3581497 | — | — | 1 | 8.36 |
| CHEMBL3581504 | — | — | 1 | 8.05 |
| CHEMBL3581501 | — | — | 1 | 7.66 |
| CHEMBL3581478 | — | — | 1 | 7.00 |
| CHEMBL3581476 | — | — | 1 | 6.92 |
| CHEMBL3581491 | — | — | 1 | 6.89 |
| CHEMBL3581505 | — | — | 1 | 6.60 |
| CHEMBL3581486 | — | — | 1 | 6.50 |
| CHEMBL3581485 | — | — | 1 | 6.46 |
| CHEMBL3581483 | — | — | 1 | 6.33 |
| CHEMBL3581475 | — | — | 1 | 6.27 |
| CHEMBL3581487 | — | — | 1 | 6.06 |
| CHEMBL3581488 | — | — | 1 | 6.02 |
| CHEMBL3581494 | — | — | 1 | 5.84 |
| CHEMBL3581482 | — | — | 1 | 5.65 |
| CHEMBL3581492 | — | — | 1 | 5.52 |
| CHEMBL3581481 | — | — | 1 | 5.49 |
| CHEMBL3581489 | — | — | 1 | 5.23 |
| CHEMBL3581474 | — | — | 1 | - |
| CHEMBL1761273 | — | — | 1 | - |
| CHEMBL3581477 | — | — | 1 | - |
| CHEMBL3581480 | — | — | 1 | - |
| CHEMBL3581484 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3581500 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3581498 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3581479 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3581502 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3581499 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3581503 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3581497 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3581504 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL3581501 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3581478 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3581476 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3581491 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3581505 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3581486 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3581485 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3581483 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3581475 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3581487 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3581488 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL3581494 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL3581482 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL3581492 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3581481 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL3581489 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3581474 | — | IC50 | - | — | - | |
| CHEMBL1761273 | — | IC50 | - | — | - | |
| CHEMBL3581477 | — | IC50 | - | — | - | |
| CHEMBL3581480 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3581484 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3581490 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3581496 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3581495 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3581493 | — | IC50 | > | 5000.0 | nM | - |