Compound Detail
CHEMBL1761273
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Basic Information
| ChEMBL ID | CHEMBL1761273 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JABURMIKTRZXPS-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
298.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 5.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Ki | 5.51 | 5.51 | 3110.0 | 1 |
| Beta-lactamase CHEMBL2725 | Ki | 5.26 | 5.26 | 5550.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Ki | = | 3110.0 | nM | 5.51 | Inhibition of beta-lactamase TEM1 using nitrocefin as substrate after 30 mins by... | 21392987 |
| Beta-lactamase | Ki | = | 5550.0 | nM | 5.26 | Inhibition of Enterobacter cloacae P99 beta-lactamase AmpC P99 using nitrocefin ... | 21392987 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21392987 | 10.1016/j.bmcl.2011.02.024 | Unchecked | 3 |
| 26067904 | 10.1021/acs.jmedchem.5b00678 | Plasmodium falciparum | 2 |
| 21392987 | 10.1016/j.bmcl.2011.02.024 | Beta-lactamase | 1 |
Data from ChEMBL 36 via Core Engine