Assay Detail
Binding
CHEMBL1763746
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Inhibition of Enterobacter cloacae P99 beta-lactamase AmpC P99 using nitrocefin as substrate after 30 mins by spectrophotometric analysis
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Enterobacter cloacae |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 5.37 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1761274 | — | — | 1 | 7.70 |
| CHEMBL1761275 | — | — | 1 | 7.70 |
| CHEMBL1761276 | — | — | 1 | 7.10 |
| CHEMBL1761091 | — | — | 1 | 6.15 |
| CHEMBL1761261 | — | — | 1 | 5.87 |
| CHEMBL1761268 | — | — | 1 | 5.84 |
| CHEMBL1761266 | — | — | 1 | 5.64 |
| CHEMBL1761263 | — | — | 1 | 5.56 |
| CHEMBL1761265 | — | — | 1 | 5.48 |
| CHEMBL1761260 | — | — | 1 | 5.33 |
| CHEMBL1761273 | — | — | 1 | 5.26 |
| CHEMBL1761269 | — | — | 1 | 5.22 |
| CHEMBL1761095 | — | — | 1 | 5.14 |
| CHEMBL1761267 | — | — | 1 | 5.11 |
| CHEMBL1761264 | — | — | 1 | 5.08 |
| CHEMBL1761270 | — | — | 1 | 5.06 |
| CHEMBL1761092 | — | — | 1 | 5.04 |
| CHEMBL1761271 | — | — | 1 | 4.88 |
| CHEMBL1761259 | — | — | 1 | 4.80 |
| CHEMBL1761093 | — | — | 1 | 4.70 |
| CHEMBL1761094 | — | — | 1 | 4.55 |
| CHEMBL1761272 | — | — | 1 | 4.39 |
| CHEMBL1761258 | — | — | 1 | 4.33 |
| CHEMBL1761096 | — | — | 1 | 4.24 |
| CHEMBL1761257 | — | — | 1 | 4.20 |
| CHEMBL1761262 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1761274 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL1761275 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL1761276 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL1761091 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL1761261 | — | Ki | = | 1350.0 | nM | 5.87 |
| CHEMBL1761268 | — | Ki | = | 1440.0 | nM | 5.84 |
| CHEMBL1761266 | — | Ki | = | 2270.0 | nM | 5.64 |
| CHEMBL1761263 | — | Ki | = | 2750.0 | nM | 5.56 |
| CHEMBL1761265 | — | Ki | = | 3330.0 | nM | 5.48 |
| CHEMBL1761260 | — | Ki | = | 4730.0 | nM | 5.33 |
| CHEMBL1761273 | — | Ki | = | 5550.0 | nM | 5.26 |
| CHEMBL1761269 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL1761095 | — | Ki | = | 7280.0 | nM | 5.14 |
| CHEMBL1761267 | — | Ki | = | 7720.0 | nM | 5.11 |
| CHEMBL1761264 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL1761270 | — | Ki | = | 8730.0 | nM | 5.06 |
| CHEMBL1761092 | — | Ki | = | 9090.0 | nM | 5.04 |
| CHEMBL1761271 | — | Ki | = | 13300.0 | nM | 4.88 |
| CHEMBL1761259 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL1761093 | — | Ki | = | 19790.0 | nM | 4.70 |
| CHEMBL1761094 | — | Ki | = | 28470.0 | nM | 4.55 |
| CHEMBL1761272 | — | Ki | = | 40630.0 | nM | 4.39 |
| CHEMBL1761258 | — | Ki | = | 46560.0 | nM | 4.33 |
| CHEMBL1761096 | — | Ki | = | 57980.0 | nM | 4.24 |
| CHEMBL1761257 | — | Ki | = | 63220.0 | nM | 4.20 |
| CHEMBL1761262 | — | Ki | - | — | - |