Compound Detail
CHEMBL1761264
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Basic Information
| ChEMBL ID | CHEMBL1761264 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JEXHHBKLEOAAKS-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
256.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 5.87
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Ki | 5.87 | 5.5533 | 1360.0 | 3 |
| Beta-lactamase CHEMBL2725 | Ki | 5.08 | 5.08 | 8400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Ki | = | 1360.0 | nM | 5.87 | Inhibition of beta-lactamase TEM1 using nitrocefin as substrate after 30 mins by... | 21392987 |
| Unchecked | Ki | = | 1920.0 | nM | 5.72 | Inhibition of beta-lactamase CTX-M9a using nitrocefin as substrate after 30 mins... | 21392987 |
| Beta-lactamase | Ki | = | 8400.0 | nM | 5.08 | Inhibition of Enterobacter cloacae P99 beta-lactamase AmpC P99 using nitrocefin ... | 21392987 |
| Unchecked | Ki | = | 8430.0 | nM | 5.07 | Inhibition of beta-lactamase CMY-2 using nitrocefin as substrate after 30 mins b... | 21392987 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21392987 | 10.1016/j.bmcl.2011.02.024 | Unchecked | 3 |
| 21392987 | 10.1016/j.bmcl.2011.02.024 | Beta-lactamase | 1 |
Data from ChEMBL 36 via Core Engine