Assay Detail
Binding
CHEMBL3587028
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3-Kinase γ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 10.49 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3586674 | — | — | 1 | 11.00 |
| CHEMBL3586672 | — | — | 1 | 10.96 |
| CHEMBL3586668 | — | — | 1 | 10.89 |
| CHEMBL3586673 | — | — | 1 | 10.80 |
| CHEMBL3586670 | — | — | 1 | 10.77 |
| CHEMBL3586669 | — | — | 1 | 10.62 |
| CHEMBL3586680 | — | — | 1 | 10.60 |
| CHEMBL3586675 | — | — | 1 | 10.47 |
| CHEMBL3586666 | — | — | 1 | 10.32 |
| CHEMBL3586671 | — | — | 1 | 10.18 |
| CHEMBL3586665 | — | — | 1 | 9.80 |
| CHEMBL3586667 | — | — | 1 | 9.48 |
| CHEMBL3586676 | — | — | 1 | - |
| CHEMBL3586677 | — | — | 1 | - |
| CHEMBL3586678 | — | — | 1 | - |
| CHEMBL3585362 | — | — | 1 | - |
| CHEMBL3586679 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3586674 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL3586672 | — | Ki | = | 0.011 | nM | 10.96 |
| CHEMBL3586668 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL3586673 | — | Ki | = | 0.016 | nM | 10.80 |
| CHEMBL3586670 | — | Ki | = | 0.017 | nM | 10.77 |
| CHEMBL3586669 | — | Ki | = | 0.024 | nM | 10.62 |
| CHEMBL3586680 | — | Ki | = | 0.025 | nM | 10.60 |
| CHEMBL3586675 | — | Ki | = | 0.034 | nM | 10.47 |
| CHEMBL3586666 | — | Ki | = | 0.048 | nM | 10.32 |
| CHEMBL3586671 | — | Ki | = | 0.066 | nM | 10.18 |
| CHEMBL3586665 | — | Ki | = | 0.157 | nM | 9.80 |
| CHEMBL3586667 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL3586676 | — | Ki | = | 0.006 | nM | - |
| CHEMBL3586677 | — | Ki | = | 0.003 | nM | - |
| CHEMBL3586678 | — | Ki | = | 0.002 | nM | - |
| CHEMBL3585362 | — | Ki | = | 0.003 | nM | - |
| CHEMBL3586679 | — | Ki | = | 0.009 | nM | - |