Compound Detail
CHEMBL3586672
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Basic Information
| ChEMBL ID | CHEMBL3586672 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HEZDNJBRVAQMFB-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
391.5
MW (Da)
2.66
ALogP
7
HBA
2
HBD
88.6
PSA (Ų)
0.67
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 10.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform CHEMBL3267 | Ki | 10.96 | 10.96 | 0.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Ki | = | 0.011 | nM | 10.96 | Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 1... | 26121481 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26121481 | 10.1021/acs.jmedchem.5b00498 | Unchecked | 3 |
| 26121481 | 10.1021/acs.jmedchem.5b00498 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
Data from ChEMBL 36 via Core Engine