Assay Detail
Functional
CHEMBL3587064
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Anticancer activity against human Saos2 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SAOS-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimitotic activity of structurally simplified biaryl analogs of the anticancer agents colchicine and combretastatin A4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.32 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.94 |
| CHEMBL81794 | — | — | 1 | 5.75 |
| CHEMBL3585529 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL81794 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL3585529 | — | IC50 | = | 5430.0 | nM | 5.26 |