Assay Detail
Binding
CHEMBL3587362
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Inhibition of PI3K-alpha (unknown origin) by mobility shift assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.59 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3586382 | — | — | 1 | 7.00 |
| CHEMBL3586384 | — | — | 1 | 6.92 |
| CHEMBL3586383 | — | — | 1 | 6.70 |
| CHEMBL3586387 | — | — | 1 | 6.29 |
| CHEMBL2348864 | — | — | 1 | 6.28 |
| CHEMBL3586385 | — | — | 1 | 5.80 |
| CHEMBL3586401 | — | — | 1 | 5.72 |
| CHEMBL3586386 | — | — | 1 | 5.64 |
| CHEMBL3586397 | — | — | 1 | 5.60 |
| CHEMBL3586400 | — | — | 1 | 5.55 |
| CHEMBL3586393 | — | — | 1 | 5.50 |
| CHEMBL3586394 | — | — | 1 | 5.42 |
| CHEMBL3586404 | ONATASERTIB | 2.0 | 1 | 5.40 |
| CHEMBL3586392 | — | — | 1 | 5.33 |
| CHEMBL3586399 | — | — | 1 | 5.33 |
| CHEMBL3586391 | — | — | 1 | 5.21 |
| CHEMBL3586396 | — | — | 1 | 5.12 |
| CHEMBL3586390 | — | — | 1 | 4.98 |
| CHEMBL3586402 | — | — | 1 | 4.96 |
| CHEMBL3586403 | — | — | 1 | 4.79 |
| CHEMBL3586395 | — | — | 1 | 4.75 |
| CHEMBL3586398 | — | — | 1 | 4.70 |
| CHEMBL3585359 | — | — | 1 | - |
| CHEMBL3586388 | — | — | 1 | - |
| CHEMBL3586379 | — | — | 1 | - |
| CHEMBL3586380 | — | — | 1 | - |
| CHEMBL3586381 | — | — | 1 | - |
| CHEMBL3586389 | — | — | 1 | - |
| CHEMBL2348862 | — | — | 1 | - |
| CHEMBL3586405 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3586382 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3586384 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3586383 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3586387 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL2348864 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3586385 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3586401 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3586386 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3586397 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3586400 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3586393 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3586394 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3586404 | ONATASERTIB | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3586392 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3586399 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3586391 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3586396 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL3586390 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL3586402 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL3586403 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL3586395 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL3586398 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL3585359 | — | IC50 | - | — | - | |
| CHEMBL3586388 | — | IC50 | - | — | - | |
| CHEMBL3586379 | — | IC50 | - | — | - | |
| CHEMBL3586380 | — | IC50 | - | — | - | |
| CHEMBL3586381 | — | IC50 | - | — | - | |
| CHEMBL3586389 | — | IC50 | - | — | - | |
| CHEMBL2348862 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3586405 | — | IC50 | > | 30000.0 | nM | - |