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Assay Detail

CHEMBL3587631

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ADMET
Cytotoxicity against rat L6 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Synthesis and evaluation of artesunateindoloquinoline hybrids as antimalarial drug candidates
Wang N, Wicht KJ, Shaban E, Ngoc TA, Wang M, Hayashi I, Hossain MI, Takemasa Y, Kaiser M, El Tantawy El Sayed I, Egan TJ, Inokuchi T
Medchemcomm (2014) 5 : 927 -931
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.98 6.56

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3585413 1 6.56
CHEMBL2058009 1 6.55
CHEMBL2391246 1 6.47
CHEMBL3233348 1 6.20
CHEMBL3585409 1 6.16
CHEMBL3585407 1 6.00
CHEMBL3585410 1 5.91
CHEMBL3585406 1 5.89
CHEMBL3585404 1 5.82
CHEMBL3585411 1 5.66
CHEMBL3585412 1 5.58
CHEMBL3585405 1 5.53
CHEMBL3585408 1 5.43

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3585413 IC50 = 275.5 nM 6.56
CHEMBL2058009 IC50 = 279.2 nM 6.55
CHEMBL2391246 IC50 = 337.0 nM 6.47
CHEMBL3233348 IC50 = 626.8 nM 6.20
CHEMBL3585409 IC50 = 695.0 nM 6.16
CHEMBL3585407 IC50 = 991.3 nM 6.00
CHEMBL3585410 IC50 = 1223.1 nM 5.91
CHEMBL3585406 IC50 = 1284.6 nM 5.89
CHEMBL3585404 IC50 = 1529.5 nM 5.82
CHEMBL3585411 IC50 = 2201.0 nM 5.66
CHEMBL3585412 IC50 = 2618.8 nM 5.58
CHEMBL3585405 IC50 = 2962.0 nM 5.53
CHEMBL3585408 IC50 = 3718.3 nM 5.43