Assay Detail
Binding
CHEMBL3587908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PTP1B using p-NPP as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by microplate reader analysis
16
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.17 | 5.47 |
| Inhibition | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 5.47 |
| CHEMBL515252 | — | — | 2 | 5.35 |
| CHEMBL272861 | TAIWANIAFLAVONE | — | 2 | 5.27 |
| CHEMBL63677 | ROBUSTAFLAVONE | — | 2 | 5.21 |
| CHEMBL63354 | AMENTOFLAVONE | — | 2 | 5.13 |
| CHEMBL1208973 | CUPRESSUFLAVONE | — | 2 | 5.02 |
| CHEMBL3585680 | — | — | 2 | 5.01 |
| CHEMBL3585679 | — | — | 2 | 4.88 |
| CHEMBL426373 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL515252 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL272861 | TAIWANIAFLAVONE | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL63677 | ROBUSTAFLAVONE | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL63354 | AMENTOFLAVONE | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL1208973 | CUPRESSUFLAVONE | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL3585680 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL3585679 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL426373 | — | IC50 | = | 4500.0 | nM | - |
| CHEMBL63354 | AMENTOFLAVONE | Inhibition | - | % | - | |
| CHEMBL63677 | ROBUSTAFLAVONE | Inhibition | - | % | - | |
| CHEMBL1208973 | CUPRESSUFLAVONE | Inhibition | - | % | - | |
| CHEMBL272861 | TAIWANIAFLAVONE | Inhibition | - | % | - | |
| CHEMBL515252 | — | Inhibition | - | % | - | |
| CHEMBL3585679 | — | Inhibition | - | % | - | |
| CHEMBL3585680 | — | Inhibition | - | % | - |