Assay Detail
Binding
CHEMBL3587976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Mixed-competitive inhibition of human recombinant PTP1B using p-NPP as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by Lineweaver-Burk/Dixon plot analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.17 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272861 | TAIWANIAFLAVONE | — | 1 | 5.35 |
| CHEMBL515252 | — | — | 1 | 5.34 |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 5.19 |
| CHEMBL63677 | ROBUSTAFLAVONE | — | 1 | 5.17 |
| CHEMBL63354 | AMENTOFLAVONE | — | 1 | 5.11 |
| CHEMBL3585679 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272861 | TAIWANIAFLAVONE | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL515252 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL169 | URSOLIC ACID | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL63677 | ROBUSTAFLAVONE | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL63354 | AMENTOFLAVONE | Ki | = | 7800.0 | nM | 5.11 |
| CHEMBL3585679 | — | Ki | = | 14500.0 | nM | 4.84 |