Assay Detail
Functional
CHEMBL3588321
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as reduction of virus-induced cytopathogenicity
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.91 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 8.00 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 7.70 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 6.70 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 6.00 |
| CHEMBL3586165 | — | — | 1 | 4.35 |
| CHEMBL3586161 | — | — | 1 | 4.35 |
| CHEMBL3586160 | — | — | 1 | 4.30 |
| CHEMBL3586164 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3586165 | — | EC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL3586161 | — | EC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL3586160 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3586164 | — | EC50 | > | 100000.0 | nM | - |