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Assay Detail

CHEMBL3588324

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antibacterial activity against Escherichia coli CECT 405 assessed as inhibition of microbial growth incubated for 18 hrs by 2-fold microtiter broth dilution method
21
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Escherichia coli
Confidence 1 — Organism
Curated By Autocuration

Target

Escherichia coli (CHEMBL354)
Type ORGANISM
Organism Escherichia coli

Publication

Synthesis and antibacterial activities of cadiolides A, B and C and analogues.
Boulangé A, Parraga J, Galán A, Cabedo N, Leleu S, Sanz MJ, Cortes D, Franck X.
Bioorg Med Chem (2015) 23 : 3618 -3628
PubMed 25913865 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
MIC 17 - -
IC50 4 5.43 5.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3585711 2 5.57
CHEMBL3585709 2 5.51
CHEMBL3585716 2 5.44
CHEMBL3585717 2 5.20
CHEMBL3585710 1 -
CHEMBL2204150 CADIOLIDE C 1 -
CHEMBL3585715 1 -
CHEMBL3585712 1 -
CHEMBL2204154 CADIOLIDE B 1 -
CHEMBL1440 TETRACYCLINE 4.0 1 -
CHEMBL3585704 1 -
CHEMBL3585705 1 -
CHEMBL3585706 1 -
CHEMBL3585707 1 -
CHEMBL3585708 1 -
CHEMBL3585713 1 -
CHEMBL3585714 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3585711 IC50 = 2720.0 nM 5.57
CHEMBL3585709 IC50 = 3060.0 nM 5.51
CHEMBL3585716 IC50 = 3660.0 nM 5.44
CHEMBL3585717 IC50 = 6380.0 nM 5.20
CHEMBL3585716 MIC = 1.95 ug.mL-1 -
CHEMBL3585715 MIC = 31.25 ug.mL-1 -
CHEMBL3585714 MIC = 7.81 ug.mL-1 -
CHEMBL3585713 MIC = 7.81 ug.mL-1 -
CHEMBL3585708 MIC = 15.62 ug.mL-1 -
CHEMBL3585707 MIC = 15.62 ug.mL-1 -
CHEMBL3585706 MIC = 125.0 ug.mL-1 -
CHEMBL3585705 MIC > 125.0 ug.mL-1 -
CHEMBL3585704 MIC = 62.5 ug.mL-1 -
CHEMBL3585717 MIC = 3.9 ug.mL-1 -
CHEMBL2204154 CADIOLIDE B MIC = 7.81 ug.mL-1 -
CHEMBL3585712 MIC = 1.95 ug.mL-1 -
CHEMBL3585711 MIC = 1.95 ug.mL-1 -
CHEMBL2204150 CADIOLIDE C MIC = 3.9 ug.mL-1 -
CHEMBL3585710 MIC = 3.9 ug.mL-1 -
CHEMBL3585709 MIC = 1.95 ug.mL-1 -
CHEMBL1440 TETRACYCLINE MIC = 7.81 ug.mL-1 -