Assay Detail
Binding
CHEMBL3588578
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Inhibition of acetylcholinesterase (unknown origin) assessed as AChI hydrolysis using AChI and DTNB as substrate by Ellman's method
21
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: novel sulfamoylcarbamates and sulfamides derived from acetophenones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 9.66 | 10.98 |
| IC50 | 10 | 10.57 | 10.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3585779 | — | — | 2 | 10.98 |
| CHEMBL3585778 | — | — | 2 | 10.64 |
| CHEMBL3585777 | — | — | 2 | 10.57 |
| CHEMBL3585776 | — | — | 2 | 10.57 |
| CHEMBL3585775 | — | — | 2 | 10.57 |
| CHEMBL3585780 | — | — | 2 | 10.57 |
| CHEMBL3585781 | — | — | 2 | 10.57 |
| CHEMBL3585782 | — | — | 2 | 10.57 |
| CHEMBL3585783 | — | — | 2 | 10.57 |
| CHEMBL3585784 | — | — | 2 | 10.57 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3585779 | — | Ki | = | 0.0105 | nM | 10.98 |
| CHEMBL3585778 | — | Ki | = | 0.0229 | nM | 10.64 |
| CHEMBL3585784 | — | IC50 | = | 0.02685 | nM | 10.57 |
| CHEMBL3585777 | — | IC50 | = | 0.02685 | nM | 10.57 |
| CHEMBL3585783 | — | IC50 | = | 0.02685 | nM | 10.57 |
| CHEMBL3585782 | — | IC50 | = | 0.02685 | nM | 10.57 |
| CHEMBL3585781 | — | IC50 | = | 0.02685 | nM | 10.57 |
| CHEMBL3585780 | — | IC50 | = | 0.02685 | nM | 10.57 |
| CHEMBL3585779 | — | IC50 | = | 0.02685 | nM | 10.57 |
| CHEMBL3585778 | — | IC50 | = | 0.02685 | nM | 10.57 |
| CHEMBL3585775 | — | IC50 | = | 0.02685 | nM | 10.57 |
| CHEMBL3585776 | — | IC50 | = | 0.02685 | nM | 10.57 |
| CHEMBL3585780 | — | Ki | = | 0.0382 | nM | 10.42 |
| CHEMBL659 | GALANTAMINE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL3585777 | — | Ki | = | 0.0051 | nM | - |
| CHEMBL3585776 | — | Ki | = | 0.0045 | nM | - |
| CHEMBL3585775 | — | Ki | = | 0.0056 | nM | - |
| CHEMBL3585781 | — | Ki | = | 0.0063 | nM | - |
| CHEMBL3585782 | — | Ki | = | 0.0049 | nM | - |
| CHEMBL3585783 | — | Ki | = | 0.0056 | nM | - |
| CHEMBL3585784 | — | Ki | = | 0.0081 | nM | - |