Assay Detail
Binding
CHEMBL3590744
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of (-)-[3H]vesamicol from VAChT in Sprague-Dawley rat brain membranes incubated for 2 hrs by liquid scintillation counting based competitive radioligand binding assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vesicular acetylcholine transporter (CHEMBL2125) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter - A critical examination of the lead structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.36 | 7.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87379 | BENZOVESAMICOL | — | 1 | 7.63 |
| CHEMBL20730 | VESAMICOL | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87379 | BENZOVESAMICOL | Ki | = | 23.4 | nM | 7.63 |
| CHEMBL20730 | VESAMICOL | Ki | = | 84.2 | nM | 7.08 |