Assay Detail
Functional
CHEMBL3590977
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Antiviral activity against influenza A virus (A/Hanfang/359/95(H3N2)) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenic effect dosed 1 hr after viral adsorption
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiviral Matrine-Type Alkaloids from the Rhizomes of Sophora tonkinensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.87 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229 | OSELTAMIVIR | 4.0 | 1 | 5.97 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.23 |
| CHEMBL3590540 | — | — | 1 | 4.20 |
| CHEMBL441175 | — | — | 1 | 4.07 |
| CHEMBL3590541 | — | — | 1 | - |
| CHEMBL380410 | OXYSOPHOCARPINE | — | 1 | - |
| CHEMBL3588877 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229 | OSELTAMIVIR | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL1643 | RIBAVIRIN | IC50 | = | 5860.0 | nM | 5.23 |
| CHEMBL3590540 | — | IC50 | = | 63070.0 | nM | 4.20 |
| CHEMBL441175 | — | IC50 | = | 84700.0 | nM | 4.07 |
| CHEMBL3590541 | — | IC50 | = | 242460.0 | nM | - |
| CHEMBL380410 | OXYSOPHOCARPINE | IC50 | = | 402820.0 | nM | - |
| CHEMBL3588877 | — | IC50 | = | 440140.0 | nM | - |