Assay Detail
Binding
CHEMBL3591180
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Inhibition of human recombinant CDK9 expressed in insect cells using CDK7/9 tide as substrate after 30 mins by scintillation counting analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.02 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589663 | — | — | 1 | 6.92 |
| CHEMBL3589661 | — | — | 1 | 6.80 |
| CHEMBL3589673 | — | — | 1 | 6.68 |
| CHEMBL3589774 | — | — | 1 | 6.46 |
| CHEMBL3589665 | — | — | 1 | 6.00 |
| CHEMBL3589666 | — | — | 1 | 5.82 |
| CHEMBL3589672 | — | — | 1 | 5.82 |
| CHEMBL3589775 | — | — | 1 | 5.70 |
| CHEMBL3589671 | — | — | 1 | 5.66 |
| CHEMBL3589674 | — | — | 1 | 5.51 |
| CHEMBL3589660 | — | — | 1 | 4.82 |
| CHEMBL3589662 | — | — | 1 | - |
| CHEMBL3589664 | — | — | 1 | - |
| CHEMBL3589667 | — | — | 1 | - |
| CHEMBL3589670 | — | — | 1 | - |
| CHEMBL3589675 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589663 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3589661 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3589673 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3589774 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3589665 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3589666 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3589672 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3589775 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3589671 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3589674 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3589660 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3589662 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3589664 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3589667 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3589670 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3589675 | — | IC50 | > | 10000.0 | nM | - |