Compound Detail
CHEMBL3589774
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Basic Information
| ChEMBL ID | CHEMBL3589774 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JVOJITSSVWIBHZ-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
302.7
MW (Da)
4.28
ALogP
3
HBA
2
HBD
66.0
PSA (Ų)
0.55
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity protein kinase CLK1 CHEMBL1075280 | IC50 | 7.28 | 7.28 | 53.0 | 1 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A CHEMBL2292 | IC50 | 6.77 | 6.77 | 170.0 | 1 |
| Cyclin-dependent kinase 9 CHEMBL3116 | IC50 | 6.46 | 6.46 | 350.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.37 | 5.37 | 4300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity protein kinase CLK1 | IC50 | = | 53.0 | nM | 7.28 | Inhibition of mouse recombinant CLK1 expressed in Escherichia coli using RS pept... | 25730262 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | IC50 | = | 170.0 | nM | 6.77 | Inhibition of human recombinant DYRK1A expressed in Escherichia coli using RS pe... | 25730262 |
| Cyclin-dependent kinase 9 | IC50 | = | 350.0 | nM | 6.46 | Inhibition of human recombinant CDK9 expressed in insect cells using CDK7/9 tide... | 25730262 |
| Unchecked | IC50 | = | 4300.0 | nM | 5.37 | Inhibition of pig brain GSK3 using GS-1 peptide as substrate after 30 mins by sc... | 25730262 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25730262 | 10.1021/jm501994d | Unchecked | 3 |
| 25730262 | 10.1021/jm501994d | Cyclin-dependent kinase 2 | 1 |
| 25730262 | 10.1021/jm501994d | Cyclin-dependent kinase 5 | 1 |
| 25730262 | 10.1021/jm501994d | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 1 |
| 25730262 | 10.1021/jm501994d | Cyclin-dependent kinase 9 | 1 |
| 25730262 | 10.1021/jm501994d | Dual specificity protein kinase CLK1 | 1 |
Data from ChEMBL 36 via Core Engine