Assay Detail
Binding
CHEMBL3591298
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Binding affinity to human ER-beta ligand binding domain after 2 hrs by competitive fluorometric binding assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 6.54 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589358 | — | — | 1 | 7.41 |
| CHEMBL3589346 | — | — | 1 | 7.31 |
| CHEMBL3589360 | — | — | 1 | 7.30 |
| CHEMBL3589368 | — | — | 1 | 7.25 |
| CHEMBL3589363 | — | — | 1 | 7.22 |
| CHEMBL3589353 | — | — | 1 | 7.17 |
| CHEMBL3589355 | — | — | 1 | 7.09 |
| CHEMBL3589352 | — | — | 1 | 7.06 |
| CHEMBL3589356 | — | — | 1 | 7.04 |
| CHEMBL3589359 | — | — | 1 | 7.02 |
| CHEMBL3589701 | — | — | 1 | 6.99 |
| CHEMBL3589367 | — | — | 1 | 6.99 |
| CHEMBL3589357 | — | — | 1 | 6.99 |
| CHEMBL3589361 | — | — | 1 | 6.92 |
| CHEMBL3589351 | — | — | 1 | 6.90 |
| CHEMBL3589362 | — | — | 1 | 6.70 |
| CHEMBL3589364 | — | — | 1 | 6.59 |
| CHEMBL3589365 | — | — | 1 | 6.32 |
| CHEMBL3589354 | — | — | 1 | 6.21 |
| CHEMBL3589350 | — | — | 1 | 6.20 |
| CHEMBL3588865 | — | — | 1 | 6.18 |
| CHEMBL3589347 | — | — | 1 | 6.12 |
| CHEMBL3589349 | — | — | 1 | 6.11 |
| CHEMBL3589700 | — | — | 1 | 6.09 |
| CHEMBL3589366 | — | — | 1 | 6.01 |
| CHEMBL3589348 | — | — | 1 | 5.85 |
| CHEMBL3589696 | — | — | 1 | 5.67 |
| CHEMBL3589699 | — | — | 1 | 5.62 |
| CHEMBL3589697 | — | — | 1 | 5.55 |
| CHEMBL3589369 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589358 | — | Ki | = | 39.04 | nM | 7.41 |
| CHEMBL3589346 | — | Ki | = | 49.06 | nM | 7.31 |
| CHEMBL3589360 | — | Ki | = | 49.78 | nM | 7.30 |
| CHEMBL3589368 | — | Ki | = | 55.65 | nM | 7.25 |
| CHEMBL3589363 | — | Ki | = | 60.5 | nM | 7.22 |
| CHEMBL3589353 | — | Ki | = | 67.73 | nM | 7.17 |
| CHEMBL3589355 | — | Ki | = | 81.53 | nM | 7.09 |
| CHEMBL3589352 | — | Ki | = | 87.32 | nM | 7.06 |
| CHEMBL3589356 | — | Ki | = | 91.89 | nM | 7.04 |
| CHEMBL3589359 | — | Ki | = | 95.24 | nM | 7.02 |
| CHEMBL3589701 | — | Ki | = | 102.41 | nM | 6.99 |
| CHEMBL3589367 | — | Ki | = | 101.49 | nM | 6.99 |
| CHEMBL3589357 | — | Ki | = | 101.49 | nM | 6.99 |
| CHEMBL3589361 | — | Ki | = | 121.43 | nM | 6.92 |
| CHEMBL3589351 | — | Ki | = | 126.87 | nM | 6.90 |
| CHEMBL3589362 | — | Ki | = | 200.01 | nM | 6.70 |
| CHEMBL3589364 | — | Ki | = | 255.64 | nM | 6.59 |
| CHEMBL3589365 | — | Ki | = | 478.87 | nM | 6.32 |
| CHEMBL3589354 | — | Ki | = | 618.18 | nM | 6.21 |
| CHEMBL3589350 | — | Ki | = | 629.63 | nM | 6.20 |
| CHEMBL3588865 | — | Ki | = | 653.85 | nM | 6.18 |
| CHEMBL3589347 | — | Ki | = | 755.56 | nM | 6.12 |
| CHEMBL3589349 | — | Ki | = | 772.73 | nM | 6.11 |
| CHEMBL3589700 | — | Ki | = | 809.52 | nM | 6.09 |
| CHEMBL3589366 | — | Ki | = | 971.43 | nM | 6.01 |
| CHEMBL3589348 | — | Ki | = | 1416.67 | nM | 5.85 |
| CHEMBL3589696 | — | Ki | = | 2125.0 | nM | 5.67 |
| CHEMBL3589699 | — | Ki | = | 2428.57 | nM | 5.62 |
| CHEMBL3589697 | — | Ki | = | 2833.33 | nM | 5.55 |
| CHEMBL3589369 | — | Ki | = | 3090.9 | nM | 5.51 |
| CHEMBL3589698 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL3589694 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL3589695 | — | Ki | > | 5000.0 | nM | - |