Assay Detail
Binding
CHEMBL3591305
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Antagonist activity at ER-alpha (unknown origin) transfected in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.38 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589346 | — | — | 1 | 7.85 |
| CHEMBL3589349 | — | — | 1 | 7.30 |
| CHEMBL3589367 | — | — | 1 | 6.89 |
| CHEMBL3589361 | — | — | 1 | 6.85 |
| CHEMBL3589701 | — | — | 1 | 6.80 |
| CHEMBL3589356 | — | — | 1 | 6.34 |
| CHEMBL3589365 | — | — | 1 | 6.19 |
| CHEMBL3589364 | — | — | 1 | 6.10 |
| CHEMBL3589368 | — | — | 1 | 6.04 |
| CHEMBL3589352 | — | — | 1 | 5.97 |
| CHEMBL3588865 | — | — | 1 | 5.92 |
| CHEMBL3589363 | — | — | 1 | 5.77 |
| CHEMBL3589347 | — | — | 1 | 4.97 |
| CHEMBL3589354 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589346 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3589349 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3589367 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3589361 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3589701 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3589356 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3589365 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3589364 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3589368 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL3589352 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL3588865 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL3589363 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3589347 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL3589354 | — | IC50 | = | 115600.0 | nM | - |