Assay Detail
Binding
CHEMBL3591328
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant DYRK1B expressed in Escherichia coli using RS peptide as substrate
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (CHEMBL5543) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.09 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589661 | — | — | 1 | 7.10 |
| CHEMBL3589660 | — | — | 1 | 6.68 |
| CHEMBL3589666 | — | — | 1 | 6.64 |
| CHEMBL3589662 | — | — | 1 | 6.22 |
| CHEMBL3589665 | — | — | 1 | 6.00 |
| CHEMBL3589775 | — | — | 1 | 5.89 |
| CHEMBL3589672 | — | — | 1 | 5.85 |
| CHEMBL3589674 | — | — | 1 | 5.72 |
| CHEMBL3589664 | — | — | 1 | 5.52 |
| CHEMBL3589671 | — | — | 1 | 5.31 |
| CHEMBL3589667 | — | — | 1 | - |
| CHEMBL3589669 | — | — | 1 | - |
| CHEMBL3589670 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589661 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3589660 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3589666 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3589662 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3589665 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3589775 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3589672 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3589674 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3589664 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3589671 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL3589667 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3589669 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3589670 | — | IC50 | > | 10000.0 | nM | - |