Assay Detail
Binding
CHEMBL3591330
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Inhibition of human recombinant DYRK3 expressed in Escherichia coli using RS peptide as substrate
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 3 (CHEMBL4575) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.34 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589674 | — | — | 1 | 7.52 |
| CHEMBL3589666 | — | — | 1 | 5.85 |
| CHEMBL3589664 | — | — | 1 | 5.64 |
| CHEMBL3589660 | — | — | 1 | - |
| CHEMBL3589661 | — | — | 1 | - |
| CHEMBL3589662 | — | — | 1 | - |
| CHEMBL3589665 | — | — | 1 | - |
| CHEMBL3589667 | — | — | 1 | - |
| CHEMBL3589669 | — | — | 1 | - |
| CHEMBL3589670 | — | — | 1 | - |
| CHEMBL3589671 | — | — | 1 | - |
| CHEMBL3589672 | — | — | 1 | - |
| CHEMBL3589775 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589674 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3589666 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3589664 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3589660 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3589661 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3589662 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3589665 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3589667 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3589669 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3589670 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3589671 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3589672 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3589775 | — | IC50 | > | 10000.0 | nM | - |