Dual specificity tyrosine-phosphorylation-regulated kinase 3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt O43781. Use UniProt O43781 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O43781 as the stable identity anchor, then attach disease evidence before program review.
Dual specificity tyrosine-phosphorylation-regulated kinase 3
Review this target as Dual specificity tyrosine-phosphorylation-regulated kinase 3, mapped to UniProt O43781. Sequence length is 588 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dual specificity tyrosine-phosphorylation-regulated kinase 3 as ChEMBL target CHEMBL4575, mapped to UniProt O43781. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O43781 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
| UniProt Accession | O43781 |
| Component Type | Protein |
| Sequence Length | 588 aa |
Dual specificity tyrosine-phosphorylation-regulated kinase 3
Review this target as Dual specificity tyrosine-phosphorylation-regulated kinase 3, mapped to UniProt O43781. Sequence length is 588 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4546504 | 9.98 | IC50 | 0.104 | Preclinical |
| CHEMBL3728543 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL3728359 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5422486 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL1986943 | 8.3 | Ki | 5.012 | Preclinical |
| CHEMBL1974870 | 8.3 | Ki | 5.012 | Preclinical |
| CHEMBL2001751 | 8.1 | Ki | 7.943 | Preclinical |
| CHEMBL2006439 | 8.1 | Ki | 7.943 | Preclinical |
| CHEMBL1997129 | 8.1 | Ki | 7.943 | Preclinical |
| CHEMBL3730504 | 8.0 | IC50 | 10.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 189 | 230 | 6.2 |
| assay format | 34 | 103 | 6.1 |
| cell-based format | 3 | 33 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 214 | 6.1 |