Assay Detail

CHEMBL3591363

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Binding

Antagonist activity against beta-1 adrenergic receptor (unknown origin)

ChEMBL ↗

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Target

Beta-1 adrenergic receptor (CHEMBL213) ↗

Open DB target context

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Beta-1 adrenergic receptor (CHEMBL213) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Beta-1 adrenergic receptor

CHEMBL213

Anchored from Assay target.

Protein identity Beta-1 adrenergic receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Beta-1 adrenergic receptor (CHEMBL213) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Volume of Distribution in Drug Design.

Smith DA, Beaumont K, Maurer TS, Di L.
J Med Chem (2015) 58 : 5691 -5698
PubMed 25799158 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	2	8.30	8.80

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL423	BETAXOLOL	4.0	1	8.80
CHEMBL13	METOPROLOL	4.0	1	7.80

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL423	BETAXOLOL	Kd	=	1.585	nM	8.80
CHEMBL13	METOPROLOL	Kd	=	15.85	nM	7.80