Assay Detail
Binding
CHEMBL3591371
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to ATAD2 (unknown origin) using HuT-78 chromatin lysate incubated for 2 hrs by bromosphere competition binding assay
18
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ATPase family AAA domain-containing protein 2 (CHEMBL2150837) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.73 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3590383 | — | — | 1 | 7.50 |
| CHEMBL3590391 | — | — | 1 | 7.40 |
| CHEMBL3590405 | — | — | 2 | 7.40 |
| CHEMBL3590407 | — | — | 1 | 7.30 |
| CHEMBL3590406 | — | — | 1 | 7.20 |
| CHEMBL3590381 | — | — | 1 | 7.00 |
| CHEMBL3590385 | — | — | 1 | 7.00 |
| CHEMBL3590408 | — | — | 1 | 7.00 |
| CHEMBL3590380 | — | — | 1 | 6.70 |
| CHEMBL3590382 | — | — | 1 | 6.60 |
| CHEMBL3590389 | — | — | 1 | 6.50 |
| CHEMBL3590384 | — | — | 1 | 6.50 |
| CHEMBL3590396 | — | — | 2 | 6.30 |
| CHEMBL3590386 | — | — | 1 | 6.10 |
| CHEMBL3590394 | — | — | 1 | 5.80 |
| CHEMBL3590388 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3590383 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL3590391 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3590405 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3590405 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3590407 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL3590406 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL3590408 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3590385 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3590381 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3590380 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL3590382 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL3590384 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL3590389 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL3590396 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL3590386 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL3590396 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3590394 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL3590388 | — | IC50 | = | 3981.07 | nM | 5.40 |