Assay Detail
Binding
CHEMBL3591373
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Binding affinity to FLAG-6His-Tev-ATAD2 (950 to 1148) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysis
16
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ATPase family AAA domain-containing protein 2 (CHEMBL2150837) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 16 | 6.36 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3590391 | — | — | 2 | 7.30 |
| CHEMBL3590405 | — | — | 2 | 7.22 |
| CHEMBL3590383 | — | — | 2 | 7.10 |
| CHEMBL3590408 | — | — | 2 | 6.70 |
| CHEMBL3590396 | — | — | 2 | 6.00 |
| CHEMBL3590388 | — | — | 4 | 5.64 |
| CHEMBL3590394 | — | — | 2 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3590391 | — | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL3590391 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL3590405 | — | Kd | = | 60.0 | nM | 7.22 |
| CHEMBL3590405 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL3590383 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL3590383 | — | Kd | = | 90.0 | nM | 7.05 |
| CHEMBL3590408 | — | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL3590408 | — | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL3590396 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL3590396 | — | Kd | = | 1100.0 | nM | 5.96 |
| CHEMBL3590388 | — | Kd | = | 2300.0 | nM | 5.64 |
| CHEMBL3590388 | — | Kd | = | 2511.89 | nM | 5.60 |
| CHEMBL3590388 | — | Kd | = | 2900.0 | nM | 5.54 |
| CHEMBL3590388 | — | Kd | = | 3162.28 | nM | 5.50 |
| CHEMBL3590394 | — | Kd | = | 3200.0 | nM | 5.50 |
| CHEMBL3590394 | — | Kd | = | 3162.28 | nM | 5.50 |