Assay Detail
Functional
CHEMBL3592211
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Antiproliferative activity against human LNCAP cells after 3 days
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.30 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589383 | — | — | 1 | 7.23 |
| CHEMBL3589385 | — | — | 1 | 7.15 |
| CHEMBL3589381 | — | — | 1 | 7.10 |
| CHEMBL1082407 | ENZALUTAMIDE | 4.0 | 1 | 6.90 |
| CHEMBL3183409 | APALUTAMIDE | 4.0 | 1 | 6.76 |
| CHEMBL3588961 | — | — | 1 | 6.73 |
| CHEMBL3589380 | — | — | 1 | 6.71 |
| CHEMBL3588965 | — | — | 1 | 6.67 |
| CHEMBL3588960 | — | — | 1 | 6.46 |
| CHEMBL3588959 | — | — | 1 | 6.40 |
| CHEMBL3589387 | — | — | 1 | 6.27 |
| CHEMBL409 | BICALUTAMIDE | 4.0 | 1 | 6.13 |
| CHEMBL3589390 | — | — | 1 | 6.03 |
| CHEMBL3588964 | — | — | 1 | 5.86 |
| CHEMBL3589391 | — | — | 1 | 5.82 |
| CHEMBL3589382 | — | — | 1 | 5.70 |
| CHEMBL3588963 | — | — | 1 | 5.64 |
| CHEMBL3588968 | — | — | 1 | 5.52 |
| CHEMBL3588962 | — | — | 1 | 5.50 |
| CHEMBL3588967 | — | — | 1 | 5.47 |
| CHEMBL3589384 | — | — | 1 | - |
| CHEMBL3589386 | — | — | 1 | - |
| CHEMBL3589388 | — | — | 1 | - |
| CHEMBL3589389 | — | — | 1 | - |
| CHEMBL3588966 | — | — | 1 | - |
| CHEMBL3588969 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589383 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3589385 | — | IC50 | = | 71.4 | nM | 7.15 |
| CHEMBL3589381 | — | IC50 | = | 79.2 | nM | 7.10 |
| CHEMBL1082407 | ENZALUTAMIDE | IC50 | = | 127.1 | nM | 6.90 |
| CHEMBL3183409 | APALUTAMIDE | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL3588961 | — | IC50 | = | 184.8 | nM | 6.73 |
| CHEMBL3589380 | — | IC50 | = | 195.6 | nM | 6.71 |
| CHEMBL3588965 | — | IC50 | = | 212.2 | nM | 6.67 |
| CHEMBL3588960 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL3588959 | — | IC50 | = | 398.1 | nM | 6.40 |
| CHEMBL3589387 | — | IC50 | = | 539.8 | nM | 6.27 |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 732.7 | nM | 6.13 |
| CHEMBL3589390 | — | IC50 | = | 944.4 | nM | 6.03 |
| CHEMBL3588964 | — | IC50 | = | 1378.0 | nM | 5.86 |
| CHEMBL3589391 | — | IC50 | = | 1511.1 | nM | 5.82 |
| CHEMBL3589382 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3588963 | — | IC50 | = | 2300.4 | nM | 5.64 |
| CHEMBL3588968 | — | IC50 | = | 3005.3 | nM | 5.52 |
| CHEMBL3588962 | — | IC50 | = | 3166.7 | nM | 5.50 |
| CHEMBL3588967 | — | IC50 | = | 3374.0 | nM | 5.47 |
| CHEMBL3589384 | — | IC50 | - | — | - | |
| CHEMBL3589386 | — | IC50 | - | — | - | |
| CHEMBL3589388 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3589389 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3588966 | — | IC50 | - | — | - | |
| CHEMBL3588969 | — | IC50 | > | 10000.0 | nM | - |