Assay Detail
Binding
CHEMBL3592213
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Partial agonist activity at androgen receptor (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.82 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3588965 | — | — | 1 | 7.36 |
| CHEMBL3588959 | — | — | 1 | 7.02 |
| CHEMBL3589390 | — | — | 1 | 6.59 |
| CHEMBL3589391 | — | — | 1 | 6.32 |
| CHEMBL3589389 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3588965 | — | Ki | = | 43.3 | nM | 7.36 |
| CHEMBL3588959 | — | Ki | = | 95.3 | nM | 7.02 |
| CHEMBL3589390 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL3589391 | — | Ki | = | 481.8 | nM | 6.32 |
| CHEMBL3589389 | — | Ki | - | — | - |