Assay Detail
Binding
CHEMBL3592309
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at recombinant human P2Y14 receptor expressed in African green monkey COS7 cells co-transfected with Galphaqi assessed as stimulation of phospholipase Cbeta
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular modeling of the human P2Y14 receptor: A template for structure-based design of selective agonist ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 4.96 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228111 | — | — | 1 | 4.96 |
| CHEMBL375951 | URIDINE DIPHOSPHATE GLUCOSE | — | 1 | - |
| CHEMBL130266 | URIDINE_DIPHOSPHATE | — | 1 | - |
| CHEMBL216011 | — | — | 1 | - |
| CHEMBL1199733 | — | — | 1 | - |
| CHEMBL593830 | — | — | 1 | - |
| CHEMBL594064 | — | — | 1 | - |
| CHEMBL593125 | — | — | 1 | - |
| CHEMBL593126 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228111 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL375951 | URIDINE DIPHOSPHATE GLUCOSE | EC50 | = | 400000.0 | nM | - |
| CHEMBL130266 | URIDINE_DIPHOSPHATE | EC50 | = | 160000.0 | nM | - |
| CHEMBL216011 | — | EC50 | = | 1920.0 | nM | - |
| CHEMBL1199733 | — | EC50 | = | 5160000.0 | nM | - |
| CHEMBL593830 | — | EC50 | = | 2500000.0 | nM | - |
| CHEMBL594064 | — | EC50 | = | 361000.0 | nM | - |
| CHEMBL593125 | — | EC50 | = | 567000.0 | nM | - |
| CHEMBL593126 | — | EC50 | = | 905000.0 | nM | - |