Assay Detail
Binding
CHEMBL3592389
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse recombinant iNOS using [3H]L-arginine substrate assessed as formation of [3H]L-citruline by liquid scintillation counting analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Acetamidine-Based Nitric Oxide Synthase Inhibitors: Synthesis, Docking, and Biological Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.69 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589092 | — | — | 1 | 7.00 |
| CHEMBL107251 | 1400W | — | 1 | 7.00 |
| CHEMBL3589091 | — | — | 1 | 6.78 |
| CHEMBL3589087 | — | — | 1 | 6.37 |
| CHEMBL3589093 | — | — | 1 | 6.30 |
| CHEMBL3589086 | — | — | 1 | - |
| CHEMBL3589088 | — | — | 1 | - |
| CHEMBL3589089 | — | — | 1 | - |
| CHEMBL3589090 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589092 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL107251 | 1400W | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3589091 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL3589087 | — | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL3589093 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3589086 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3589088 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3589089 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3589090 | — | IC50 | > | 10000.0 | nM | - |