Assay Detail
Functional
CHEMBL3592467
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Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as reduction in parasite viability by parasite lactate dehydrogenase assay
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship of hybrids of Cinchona alkaloids and bile acids with in vitro antiplasmodial and antitrypanosomal activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 6.28 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589980 | — | — | 1 | 7.44 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.44 |
| CHEMBL3589982 | — | — | 1 | 7.39 |
| CHEMBL3589930 | — | — | 1 | 7.39 |
| CHEMBL3589916 | — | — | 1 | 7.36 |
| CHEMBL3589932 | — | — | 1 | 7.28 |
| CHEMBL3589914 | — | — | 1 | 7.25 |
| CHEMBL3589933 | — | — | 1 | 7.14 |
| CHEMBL3589922 | — | — | 1 | 7.13 |
| CHEMBL3589981 | — | — | 1 | 7.11 |
| CHEMBL3589924 | — | — | 1 | 7.08 |
| CHEMBL3589983 | — | — | 1 | 7.04 |
| CHEMBL3589979 | — | — | 1 | 6.94 |
| CHEMBL3589925 | — | — | 1 | 6.91 |
| CHEMBL3589935 | — | — | 1 | 6.87 |
| CHEMBL3589921 | — | — | 1 | 6.81 |
| CHEMBL3589926 | — | — | 1 | 6.77 |
| CHEMBL3589931 | — | — | 1 | 6.77 |
| CHEMBL3589934 | — | — | 1 | 6.74 |
| CHEMBL3589929 | — | — | 1 | 6.73 |
| CHEMBL3589915 | — | — | 1 | 6.71 |
| CHEMBL3589923 | — | — | 1 | 6.71 |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 6.71 |
| CHEMBL3589917 | — | — | 1 | 6.65 |
| CHEMBL3589919 | — | — | 1 | 6.62 |
| CHEMBL3589918 | — | — | 1 | 6.56 |
| CHEMBL3589927 | — | — | 1 | 6.55 |
| CHEMBL588619 | CINCHONINE | -1.0 | 1 | 6.53 |
| CHEMBL3589985 | — | — | 1 | 6.49 |
| CHEMBL3589984 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589980 | — | IC50 | = | 36.1 | nM | 7.44 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 36.2 | nM | 7.44 |
| CHEMBL3589930 | — | IC50 | = | 40.8 | nM | 7.39 |
| CHEMBL3589982 | — | IC50 | = | 40.6 | nM | 7.39 |
| CHEMBL3589916 | — | IC50 | = | 43.5 | nM | 7.36 |
| CHEMBL3589932 | — | IC50 | = | 52.8 | nM | 7.28 |
| CHEMBL3589914 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3589933 | — | IC50 | = | 71.6 | nM | 7.14 |
| CHEMBL3589922 | — | IC50 | = | 73.2 | nM | 7.13 |
| CHEMBL3589981 | — | IC50 | = | 77.2 | nM | 7.11 |
| CHEMBL3589924 | — | IC50 | = | 83.8 | nM | 7.08 |
| CHEMBL3589983 | — | IC50 | = | 92.1 | nM | 7.04 |
| CHEMBL3589979 | — | IC50 | = | 115.4 | nM | 6.94 |
| CHEMBL3589925 | — | IC50 | = | 123.5 | nM | 6.91 |
| CHEMBL3589935 | — | IC50 | = | 133.7 | nM | 6.87 |
| CHEMBL3589921 | — | IC50 | = | 154.6 | nM | 6.81 |
| CHEMBL3589926 | — | IC50 | = | 170.2 | nM | 6.77 |
| CHEMBL3589931 | — | IC50 | = | 170.9 | nM | 6.77 |
| CHEMBL3589934 | — | IC50 | = | 182.8 | nM | 6.74 |
| CHEMBL3589929 | — | IC50 | = | 186.4 | nM | 6.73 |
| CHEMBL3589915 | — | IC50 | = | 196.7 | nM | 6.71 |
| CHEMBL3589923 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL1294 | QUINIDINE | IC50 | = | 194.4 | nM | 6.71 |
| CHEMBL3589917 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL3589919 | — | IC50 | = | 240.9 | nM | 6.62 |
| CHEMBL3589918 | — | IC50 | = | 275.1 | nM | 6.56 |
| CHEMBL3589927 | — | IC50 | = | 281.2 | nM | 6.55 |
| CHEMBL588619 | CINCHONINE | IC50 | = | 292.5 | nM | 6.53 |
| CHEMBL3589985 | — | IC50 | = | 320.3 | nM | 6.49 |
| CHEMBL3589984 | — | IC50 | = | 392.2 | nM | 6.41 |
| CHEMBL3589008 | — | IC50 | = | 459.6 | nM | 6.34 |
| CHEMBL3589936 | — | IC50 | = | 592.1 | nM | 6.23 |
| CHEMBL170 | QUININE | IC50 | = | 632.7 | nM | 6.20 |
| CHEMBL3589928 | — | IC50 | = | 700.1 | nM | 6.16 |
| CHEMBL533841 | CINCHONIDINE | IC50 | = | 962.6 | nM | 6.02 |
| CHEMBL3589986 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3589920 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL3589005 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL240597 | CHENODIOL | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL3589003 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3589007 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL1478 | LITHOCHOLIC ACID | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL3589006 | — | IC50 | = | 30500.0 | nM | 4.52 |
| CHEMBL3589004 | — | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL272621 | HYODEOXYCHOLIC_ACID | IC50 | = | 40900.0 | nM | 4.39 |
| CHEMBL272041 | — | IC50 | = | 59500.0 | nM | 4.22 |
| CHEMBL406393 | DEOXYCHOLIC ACID | IC50 | = | 93600.0 | nM | 4.03 |
| CHEMBL265502 | SURAMIN | IC50 | - | — | - | |
| CHEMBL65 | CAMPTOTHECIN | IC50 | - | — | - | |
| CHEMBL1908063 | HYOCHOLIC ACID | IC50 | = | 109000.0 | nM | - |