Assay Detail
Functional
CHEMBL3592585
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Neuroprotective activity against 0.1 uM amyloid beta 42-induced toxicity in rat PC12 cells assessed as cell viability after 24 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | PC-12 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibitory activities of biflavonoids against amyloid-β peptide 42 cytotoxicity in PC-12 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.14 | 5.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1208903 | ISOGINKGETIN | — | 1 | 5.29 |
| CHEMBL453479 | KAYAFLAVONE | — | 1 | 5.28 |
| CHEMBL208908 | SCIADOPITISIN | — | 1 | 5.01 |
| CHEMBL144630 | PODOCARPUSFLAVONE B | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1208903 | ISOGINKGETIN | EC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL453479 | KAYAFLAVONE | EC50 | = | 5290.0 | nM | 5.28 |
| CHEMBL208908 | SCIADOPITISIN | EC50 | = | 9840.0 | nM | 5.01 |
| CHEMBL144630 | PODOCARPUSFLAVONE B | EC50 | = | 10770.0 | nM | 4.97 |