Assay Detail
Functional
CHEMBL3592708
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Cytotoxicity against human HCT116 cells assessed as inhibition of cell growth after 72 hrs by MTS assay
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.76 | 7.70 |
| Inhibition | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589158 | — | — | 1 | 7.70 |
| CHEMBL3589012 | — | — | 1 | 6.00 |
| CHEMBL2323033 | — | — | 1 | 5.92 |
| CHEMBL2323029 | — | — | 1 | 4.66 |
| CHEMBL3589160 | — | — | 1 | 4.51 |
| CHEMBL1956161 | — | — | 1 | - |
| CHEMBL2323028 | — | — | 1 | - |
| CHEMBL3589011 | — | — | 1 | - |
| CHEMBL3589019 | — | — | 1 | - |
| CHEMBL3589023 | — | — | 1 | - |
| CHEMBL3589025 | — | — | 1 | - |
| CHEMBL3589156 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589158 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3589012 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL2323033 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2323029 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3589160 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL1956161 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL2323028 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL3589011 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL3589019 | — | Inhibition | - | % | - | |
| CHEMBL3589023 | — | Inhibition | - | % | - | |
| CHEMBL3589025 | — | Inhibition | - | % | - | |
| CHEMBL3589156 | — | Inhibition | - | % | - |