Assay Detail
Functional
CHEMBL3592753
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HT1080 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Styryl-N-phenyl-N'-(2-chloroethyl)ureas and styrylphenylimidazolidin-2-ones as new potent microtubule-disrupting agents using combretastatin A-4 as model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.38 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.74 |
| CHEMBL3590001 | — | — | 1 | 8.64 |
| CHEMBL3590000 | — | — | 1 | 7.82 |
| CHEMBL3589999 | — | — | 1 | 7.46 |
| CHEMBL3589993 | — | — | 1 | 6.77 |
| CHEMBL3590004 | — | — | 1 | 6.40 |
| CHEMBL3589994 | — | — | 1 | 6.16 |
| CHEMBL3589995 | — | — | 1 | 5.85 |
| CHEMBL3589988 | — | — | 1 | 4.82 |
| CHEMBL3589992 | — | — | 1 | 4.80 |
| CHEMBL3589989 | — | — | 1 | 4.54 |
| CHEMBL3589987 | — | — | 1 | 4.51 |
| CHEMBL3589998 | — | — | 1 | - |
| CHEMBL3589990 | — | — | 1 | - |
| CHEMBL3589991 | — | — | 1 | - |
| CHEMBL3589997 | — | — | 1 | - |
| CHEMBL3590002 | — | — | 1 | - |
| CHEMBL3590003 | — | — | 1 | - |
| CHEMBL3589996 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3590001 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3590000 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3589999 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3589993 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3590004 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3589994 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3589995 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3589988 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3589992 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3589989 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3589987 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3589998 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3589990 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3589991 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3589997 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3590002 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3590003 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3589996 | — | IC50 | > | 20000.0 | nM | - |