Assay Detail
Functional
CHEMBL3592869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs by microplate reader analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16-4A5 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibitors of melanogenesis in B16 melanoma 4A5 cells from flower buds of Lawsonia inermis (Henna).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.56 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 4.85 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.82 |
| CHEMBL307893 | — | — | 1 | 4.32 |
| CHEMBL3589341 | — | — | 1 | 4.26 |
| CHEMBL232202 | ARBUTIN | 2.0 | 1 | - |
| CHEMBL3589199 | — | — | 1 | - |
| CHEMBL250450 | ISOQUERCETIN | 2.0 | 1 | - |
| CHEMBL402947 | SPIRAEOSIDE | — | 1 | - |
| CHEMBL233929 | GALUTEOLIN | — | 1 | - |
| CHEMBL487018 | TILIANINE | — | 1 | - |
| CHEMBL459822 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL151 | LUTEOLIN | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL50 | QUERCETIN | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL307893 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL3589341 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL232202 | ARBUTIN | IC50 | = | 174000.0 | nM | - |
| CHEMBL3589199 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL250450 | ISOQUERCETIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL402947 | SPIRAEOSIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL233929 | GALUTEOLIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL487018 | TILIANINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL459822 | — | IC50 | > | 10000.0 | nM | - |