Assay Detail
Functional
CHEMBL3594554
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Cytotoxicity against human NMC-797 cells assessed as cell viability after 48 hrs by luminescence assay
22
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NMC-797 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.87 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3593410 | — | — | 2 | 8.00 |
| CHEMBL1173445 | LARGAZOLE | — | 2 | 7.62 |
| CHEMBL3593408 | — | — | 2 | 7.53 |
| CHEMBL3593414 | — | — | 2 | 7.16 |
| CHEMBL3593411 | — | — | 2 | 7.05 |
| CHEMBL3593247 | — | — | 2 | 7.02 |
| CHEMBL3593406 | — | — | 2 | 6.97 |
| CHEMBL3593409 | — | — | 2 | 6.66 |
| CHEMBL3593412 | — | — | 2 | 6.51 |
| CHEMBL3593407 | — | — | 2 | 5.76 |
| CHEMBL3593415 | — | — | 2 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3593410 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3593410 | — | IC50 | = | 11.25 | nM | 7.95 |
| CHEMBL1173445 | LARGAZOLE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1173445 | LARGAZOLE | IC50 | = | 23.93 | nM | 7.62 |
| CHEMBL3593408 | — | IC50 | = | 29.58 | nM | 7.53 |
| CHEMBL3593408 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3593414 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3593414 | — | IC50 | = | 75.51 | nM | 7.12 |
| CHEMBL3593411 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3593411 | — | IC50 | = | 93.11 | nM | 7.03 |
| CHEMBL3593247 | — | IC50 | = | 96.38 | nM | 7.02 |
| CHEMBL3593247 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3593406 | — | IC50 | = | 106.91 | nM | 6.97 |
| CHEMBL3593406 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3593409 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3593409 | — | IC50 | = | 221.82 | nM | 6.65 |
| CHEMBL3593412 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3593412 | — | IC50 | = | 309.74 | nM | 6.51 |
| CHEMBL3593407 | — | IC50 | = | 1733.8 | nM | 5.76 |
| CHEMBL3593407 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL3593415 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL3593415 | — | IC50 | = | 4255.98 | nM | 5.37 |