Assay Detail
Functional
CHEMBL3594555
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NMC-10326 cells assessed as cell viability after 48 hrs by luminescence assay
22
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.67 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3593410 | — | — | 2 | 8.00 |
| CHEMBL1173445 | LARGAZOLE | — | 2 | 7.61 |
| CHEMBL3593408 | — | — | 2 | 7.42 |
| CHEMBL3593247 | — | — | 2 | 7.10 |
| CHEMBL3593411 | — | — | 2 | 6.92 |
| CHEMBL3593414 | — | — | 2 | 6.89 |
| CHEMBL3593406 | — | — | 2 | 6.77 |
| CHEMBL3593409 | — | — | 2 | 6.54 |
| CHEMBL3593412 | — | — | 2 | 6.26 |
| CHEMBL3593415 | — | — | 2 | 5.06 |
| CHEMBL3593407 | — | — | 2 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3593410 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3593410 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL1173445 | LARGAZOLE | IC50 | = | 24.77 | nM | 7.61 |
| CHEMBL1173445 | LARGAZOLE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3593408 | — | IC50 | = | 37.84 | nM | 7.42 |
| CHEMBL3593408 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3593247 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3593247 | — | IC50 | = | 82.6 | nM | 7.08 |
| CHEMBL3593411 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3593411 | — | IC50 | = | 122.18 | nM | 6.91 |
| CHEMBL3593414 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3593414 | — | IC50 | = | 133.97 | nM | 6.87 |
| CHEMBL3593406 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3593406 | — | IC50 | = | 172.58 | nM | 6.76 |
| CHEMBL3593409 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3593409 | — | IC50 | = | 297.85 | nM | 6.53 |
| CHEMBL3593412 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3593412 | — | IC50 | = | 545.76 | nM | 6.26 |
| CHEMBL3593415 | — | IC50 | = | 8640.0 | nM | 5.06 |
| CHEMBL3593415 | — | IC50 | = | 8649.68 | nM | 5.06 |
| CHEMBL3593407 | — | IC50 | = | 11939.88 | nM | 4.92 |
| CHEMBL3593407 | — | IC50 | = | 11940.0 | nM | 4.92 |