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Assay Detail

CHEMBL3594585

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antioxidant activity in rat liver microsomes assessed as reduction in iron-ascorbic acid-induced lipid peroxidase activity after 30 mins by TBARS assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Liver
Confidence 1 — Organism
Curated By Autocuration

Target

Liver microsome (CHEMBL2367428)
Type TISSUE
Organism Rattus norvegicus

Publication

Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects.
Lee YH, Kim HJ, Yoo H, Jung SY, Kwon BJ, Kim NJ, Jin C, Lee YS.
Bioorg Med Chem (2015) 23 : 4970 -4979
PubMed 26068017 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.77 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3593745 1 5.00
CHEMBL3593746 1 4.99
CHEMBL3593744 1 4.98
CHEMBL3593753 1 4.96
CHEMBL3593755 1 4.95
CHEMBL3593747 1 4.94
CHEMBL3593754 1 4.92
CHEMBL3593752 1 4.92
CHEMBL3593743 1 4.80
CHEMBL3593742 1 4.79
CHEMBL163316 3-O-METHYLQUERCETIN 1 4.72
CHEMBL3593740 1 4.72
CHEMBL3593741 1 4.66
CHEMBL3593749 1 4.63
CHEMBL3593751 1 4.63
CHEMBL3593748 1 4.60
CHEMBL3593750 1 4.43
CHEMBL153 TROLOX 1 4.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3593745 IC50 = 10110.0 nM 5.00
CHEMBL3593746 IC50 = 10150.0 nM 4.99
CHEMBL3593744 IC50 = 10540.0 nM 4.98
CHEMBL3593753 IC50 = 10920.0 nM 4.96
CHEMBL3593755 IC50 = 11240.0 nM 4.95
CHEMBL3593747 IC50 = 11540.0 nM 4.94
CHEMBL3593754 IC50 = 11960.0 nM 4.92
CHEMBL3593752 IC50 = 11880.0 nM 4.92
CHEMBL3593743 IC50 = 15780.0 nM 4.80
CHEMBL3593742 IC50 = 16230.0 nM 4.79
CHEMBL163316 3-O-METHYLQUERCETIN IC50 = 19000.0 nM 4.72
CHEMBL3593740 IC50 = 19180.0 nM 4.72
CHEMBL3593741 IC50 = 21800.0 nM 4.66
CHEMBL3593749 IC50 = 23290.0 nM 4.63
CHEMBL3593751 IC50 = 23320.0 nM 4.63
CHEMBL3593748 IC50 = 25090.0 nM 4.60
CHEMBL3593750 IC50 = 37370.0 nM 4.43
CHEMBL153 TROLOX IC50 = 71440.0 nM 4.15