Assay Detail
Functional
CHEMBL3594635
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Cytotoxicity against human PC3 cells by MTT method
27
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and α-Glucosidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.53 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.70 |
| CHEMBL3594157 | — | — | 1 | 4.97 |
| CHEMBL3594155 | — | — | 1 | 4.84 |
| CHEMBL3594149 | — | — | 1 | 4.62 |
| CHEMBL457601 | GANODERONE A | — | 1 | 4.54 |
| CHEMBL3594154 | — | — | 1 | 4.23 |
| CHEMBL1097154 | GANODERIC ACID S | — | 1 | 4.12 |
| CHEMBL1915761 | GANODERIOL F | — | 1 | 4.10 |
| CHEMBL1099224 | GANODERIC ACID DM | — | 2 | 4.09 |
| CHEMBL3594145 | — | — | 1 | 4.05 |
| CHEMBL3594146 | — | — | 1 | - |
| CHEMBL3594147 | — | — | 1 | - |
| CHEMBL3594148 | — | — | 1 | - |
| CHEMBL3594150 | — | — | 1 | - |
| CHEMBL3594151 | — | — | 1 | - |
| CHEMBL3594152 | — | — | 1 | - |
| CHEMBL3594153 | — | — | 1 | - |
| CHEMBL3594142 | — | — | 1 | - |
| CHEMBL3594144 | — | — | 1 | - |
| CHEMBL3594158 | — | — | 1 | - |
| CHEMBL3594159 | — | — | 1 | - |
| CHEMBL3594160 | — | — | 1 | - |
| CHEMBL1915760 | GANODERIC ACID Y | — | 1 | - |
| CHEMBL1915763 | GANODERMANONTRIOL | — | 1 | - |
| CHEMBL3594143 | — | — | 1 | - |
| CHEMBL3594156 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3594157 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL3594155 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL3594149 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL457601 | GANODERONE A | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL3594154 | — | IC50 | = | 58400.0 | nM | 4.23 |
| CHEMBL1097154 | GANODERIC ACID S | IC50 | = | 75200.0 | nM | 4.12 |
| CHEMBL1915761 | GANODERIOL F | IC50 | = | 79500.0 | nM | 4.10 |
| CHEMBL1099224 | GANODERIC ACID DM | IC50 | = | 81600.0 | nM | 4.09 |
| CHEMBL3594145 | — | IC50 | = | 88300.0 | nM | 4.05 |
| CHEMBL3594146 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3594147 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3594148 | — | IC50 | = | 132400.0 | nM | - |
| CHEMBL3594150 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3594151 | — | IC50 | = | 110500.0 | nM | - |
| CHEMBL3594152 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3594153 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3594142 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3594156 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3594158 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3594159 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1099224 | GANODERIC ACID DM | IC50 | = | 148600.0 | nM | - |
| CHEMBL3594160 | — | IC50 | = | 102900.0 | nM | - |
| CHEMBL1915760 | GANODERIC ACID Y | IC50 | = | 179800.0 | nM | - |
| CHEMBL1915763 | GANODERMANONTRIOL | IC50 | = | 105800.0 | nM | - |
| CHEMBL3594143 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3594144 | — | IC50 | > | 200000.0 | nM | - |