Assay Detail
Binding
CHEMBL3594881
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 45 | 7.14 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3593932 | — | — | 1 | 8.68 |
| CHEMBL3593930 | — | — | 1 | 8.46 |
| CHEMBL3593928 | — | — | 1 | 8.42 |
| CHEMBL3593911 | — | — | 1 | 8.38 |
| CHEMBL3593904 | — | — | 1 | 7.94 |
| CHEMBL3593926 | — | — | 1 | 7.89 |
| CHEMBL3593922 | — | — | 1 | 7.84 |
| CHEMBL3593924 | — | — | 1 | 7.60 |
| CHEMBL3593915 | — | — | 1 | 7.53 |
| CHEMBL3593909 | — | — | 1 | 7.39 |
| CHEMBL3593903 | — | — | 1 | 7.39 |
| CHEMBL3593916 | — | — | 1 | 7.36 |
| CHEMBL3593918 | — | — | 1 | 7.35 |
| CHEMBL3593913 | — | — | 1 | 7.34 |
| CHEMBL3593905 | — | — | 1 | 7.27 |
| CHEMBL3593931 | — | — | 1 | 7.27 |
| CHEMBL3593910 | — | — | 1 | 7.26 |
| CHEMBL3593902 | — | — | 1 | 7.21 |
| CHEMBL3593908 | — | — | 1 | 7.20 |
| CHEMBL3593929 | — | — | 1 | 7.19 |
| CHEMBL3593917 | — | — | 1 | 7.17 |
| CHEMBL3593914 | — | — | 1 | 7.17 |
| CHEMBL3593907 | — | — | 1 | 7.14 |
| CHEMBL3593933 | — | — | 1 | 7.12 |
| CHEMBL3593900 | — | — | 1 | 7.10 |
| CHEMBL3593927 | — | — | 1 | 7.09 |
| CHEMBL328710 | — | — | 1 | 7.07 |
| CHEMBL3593912 | — | — | 1 | 7.04 |
| CHEMBL3593896 | — | — | 1 | 6.94 |
| CHEMBL3593893 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3593932 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL3593930 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL3593928 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL3593911 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL3593904 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL3593926 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL3593922 | — | Ki | = | 14.6 | nM | 7.84 |
| CHEMBL3593924 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3593915 | — | Ki | = | 29.8 | nM | 7.53 |
| CHEMBL3593909 | — | Ki | = | 40.9 | nM | 7.39 |
| CHEMBL3593903 | — | Ki | = | 40.7 | nM | 7.39 |
| CHEMBL3593916 | — | Ki | = | 43.6 | nM | 7.36 |
| CHEMBL3593918 | — | Ki | = | 44.8 | nM | 7.35 |
| CHEMBL3593913 | — | Ki | = | 45.3 | nM | 7.34 |
| CHEMBL3593931 | — | Ki | = | 53.3 | nM | 7.27 |
| CHEMBL3593905 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL3593910 | — | Ki | = | 54.6 | nM | 7.26 |
| CHEMBL3593902 | — | Ki | = | 61.1 | nM | 7.21 |
| CHEMBL3593908 | — | Ki | = | 63.7 | nM | 7.20 |
| CHEMBL3593929 | — | Ki | = | 64.7 | nM | 7.19 |
| CHEMBL3593917 | — | Ki | = | 68.1 | nM | 7.17 |
| CHEMBL3593914 | — | Ki | = | 68.3 | nM | 7.17 |
| CHEMBL3593907 | — | Ki | = | 72.5 | nM | 7.14 |
| CHEMBL3593933 | — | Ki | = | 76.1 | nM | 7.12 |
| CHEMBL3593900 | — | Ki | = | 79.5 | nM | 7.10 |
| CHEMBL3593927 | — | Ki | = | 81.9 | nM | 7.09 |
| CHEMBL328710 | — | Ki | = | 84.4 | nM | 7.07 |
| CHEMBL3593912 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL3593896 | — | Ki | = | 114.5 | nM | 6.94 |
| CHEMBL3593893 | — | Ki | = | 124.3 | nM | 6.91 |
| CHEMBL3593895 | — | Ki | = | 144.4 | nM | 6.84 |
| CHEMBL3593897 | — | Ki | = | 149.8 | nM | 6.82 |
| CHEMBL3593925 | — | Ki | = | 192.7 | nM | 6.71 |
| CHEMBL3593901 | — | Ki | = | 206.7 | nM | 6.68 |
| CHEMBL3593923 | — | Ki | = | 211.4 | nM | 6.67 |
| CHEMBL3593906 | — | Ki | = | 226.9 | nM | 6.64 |
| CHEMBL3593252 | — | Ki | = | 290.2 | nM | 6.54 |
| CHEMBL3593899 | — | Ki | = | 350.2 | nM | 6.46 |
| CHEMBL3593898 | — | Ki | = | 342.6 | nM | 6.46 |
| CHEMBL201986 | — | Ki | = | 347.2 | nM | 6.46 |
| CHEMBL3593894 | — | Ki | = | 407.1 | nM | 6.39 |
| CHEMBL3593920 | — | Ki | = | 482.9 | nM | 6.32 |
| CHEMBL86921 | — | Ki | = | 507.6 | nM | 6.29 |
| CHEMBL3593919 | — | Ki | = | 621.8 | nM | 6.21 |
| CHEMBL3593921 | — | Ki | = | 959.3 | nM | 6.02 |