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Assay Detail

CHEMBL3594882

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of Thio-T from amyloid beta (1 to 42) (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assay
ChEMBL ↗
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amyloid-beta precursor protein (CHEMBL2487) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils.
Chu W, Zhou D, Gaba V, Liu J, Li S, Peng X, Xu J, Dhavale D, Bagchi DP, d'Avignon A, Shakerdge NB, Bacskai BJ, Tu Z, Kotzbauer PT, Mach RH.
J Med Chem (2015) 58 : 6002 -6017
PubMed 26177091 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 45 6.88 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3593904 — — 1 7.82
CHEMBL3593903 — — 1 7.56
CHEMBL3593922 — — 1 7.44
CHEMBL3593905 — — 1 7.43
CHEMBL3593893 — — 1 7.40
CHEMBL3593912 — — 1 7.34
CHEMBL3593918 — — 1 7.29
CHEMBL3593908 — — 1 7.25
CHEMBL3593923 — — 1 7.22
CHEMBL3593930 — — 1 7.13
CHEMBL3593913 — — 1 7.08
CHEMBL3593914 — — 1 7.07
CHEMBL3593897 — — 1 7.06
CHEMBL328710 — — 1 7.04
CHEMBL3593911 — — 1 7.03
CHEMBL3593894 — — 1 7.02
CHEMBL3593916 — — 1 7.00
CHEMBL3593915 — — 1 6.97
CHEMBL3593928 — — 1 6.96
CHEMBL3593900 — — 1 6.95
CHEMBL3593933 — — 1 6.90
CHEMBL3593902 — — 1 6.90
CHEMBL3593931 — — 1 6.89
CHEMBL3593910 — — 1 6.89
CHEMBL3593926 — — 1 6.88
CHEMBL3593927 — — 1 6.86
CHEMBL3593932 — — 1 6.85
CHEMBL3593898 — — 1 6.85
CHEMBL86921 — — 1 6.81
CHEMBL3593252 — — 1 6.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3593904 — Ki = 15.3 nM 7.82
CHEMBL3593903 — Ki = 27.6 nM 7.56
CHEMBL3593922 — Ki = 36.2 nM 7.44
CHEMBL3593905 — Ki = 37.1 nM 7.43
CHEMBL3593893 — Ki = 40.0 nM 7.40
CHEMBL3593912 — Ki = 45.9 nM 7.34
CHEMBL3593918 — Ki = 50.8 nM 7.29
CHEMBL3593908 — Ki = 56.0 nM 7.25
CHEMBL3593923 — Ki = 60.0 nM 7.22
CHEMBL3593930 — Ki = 73.6 nM 7.13
CHEMBL3593913 — Ki = 84.0 nM 7.08
CHEMBL3593914 — Ki = 85.1 nM 7.07
CHEMBL3593897 — Ki = 87.1 nM 7.06
CHEMBL328710 — Ki = 91.6 nM 7.04
CHEMBL3593911 — Ki = 92.4 nM 7.03
CHEMBL3593894 — Ki = 94.8 nM 7.02
CHEMBL3593916 — Ki = 98.9 nM 7.00
CHEMBL3593915 — Ki = 107.0 nM 6.97
CHEMBL3593928 — Ki = 109.7 nM 6.96
CHEMBL3593900 — Ki = 113.3 nM 6.95
CHEMBL3593933 — Ki = 125.3 nM 6.90
CHEMBL3593902 — Ki = 125.8 nM 6.90
CHEMBL3593931 — Ki = 129.5 nM 6.89
CHEMBL3593910 — Ki = 129.6 nM 6.89
CHEMBL3593926 — Ki = 130.8 nM 6.88
CHEMBL3593927 — Ki = 138.5 nM 6.86
CHEMBL3593932 — Ki = 142.4 nM 6.85
CHEMBL3593898 — Ki = 139.9 nM 6.85
CHEMBL86921 — Ki = 155.1 nM 6.81
CHEMBL3593252 — Ki = 179.2 nM 6.75
CHEMBL3593899 — Ki = 190.2 nM 6.72
CHEMBL3593924 — Ki = 214.2 nM 6.67
CHEMBL3593925 — Ki = 235.4 nM 6.63
CHEMBL3593896 — Ki = 251.5 nM 6.60
CHEMBL3593929 — Ki = 264.8 nM 6.58
CHEMBL3593895 — Ki = 260.4 nM 6.58
CHEMBL3593901 — Ki = 266.8 nM 6.57
CHEMBL3593917 — Ki = 286.8 nM 6.54
CHEMBL201986 — Ki = 325.2 nM 6.49
CHEMBL3593909 — Ki = 357.9 nM 6.45
CHEMBL3593919 — Ki = 439.2 nM 6.36
CHEMBL3593920 — Ki = 459.5 nM 6.34
CHEMBL3593921 — Ki = 694.7 nM 6.16
CHEMBL3593906 — Ki = 703.3 nM 6.15
CHEMBL3593907 — Ki = 741.0 nM 6.13