Assay Detail
Binding
CHEMBL3594892
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hedgehog signaling pathway in human HaCaT cells assessed as GLI1-mediated transcriptional activity after 12 hrs by luciferase assay
22
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HaCaT |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Hedgehog inhibitors from Artocarpus communis and Hyptis suaveolens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.71 | 5.40 |
| Inhibition | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL470287 | — | — | 2 | 5.40 |
| CHEMBL471694 | — | — | 2 | 5.33 |
| CHEMBL512307 | — | — | 2 | 5.12 |
| CHEMBL374130 | BONANNIONE A | — | 2 | 4.84 |
| CHEMBL469683 | — | — | 1 | 4.79 |
| CHEMBL523392 | — | — | 2 | 4.63 |
| CHEMBL3593940 | — | — | 1 | 4.53 |
| CHEMBL3594223 | — | — | 1 | 4.40 |
| CHEMBL3593935 | — | — | 2 | 4.40 |
| CHEMBL3593939 | — | — | 2 | 4.39 |
| CHEMBL3594224 | — | — | 1 | 4.36 |
| CHEMBL3593938 | — | — | 2 | 4.36 |
| CHEMBL3593937 | — | — | 1 | - |
| CHEMBL3593936 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL470287 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL471694 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL512307 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL374130 | BONANNIONE A | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL469683 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL523392 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL3593940 | — | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL3594223 | — | IC50 | = | 39900.0 | nM | 4.40 |
| CHEMBL3593935 | — | IC50 | = | 40100.0 | nM | 4.40 |
| CHEMBL3593939 | — | IC50 | = | 40700.0 | nM | 4.39 |
| CHEMBL3594224 | — | IC50 | = | 43500.0 | nM | 4.36 |
| CHEMBL3593938 | — | IC50 | = | 44200.0 | nM | 4.36 |
| CHEMBL471694 | — | Inhibition | - | % | - | |
| CHEMBL470287 | — | Inhibition | - | % | - | |
| CHEMBL512307 | — | Inhibition | - | % | - | |
| CHEMBL374130 | BONANNIONE A | Inhibition | - | % | - | |
| CHEMBL3593939 | — | Inhibition | - | % | - | |
| CHEMBL3593938 | — | Inhibition | - | % | - | |
| CHEMBL3593935 | — | Inhibition | - | % | - | |
| CHEMBL523392 | — | Inhibition | - | % | - | |
| CHEMBL3593936 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL3593937 | — | IC50 | > | 75000.0 | nM | - |