Assay Detail
Binding
CHEMBL3595067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant TF/F7a complex using S2288 as substrate preincubated for 15 mins followed by protein addition measured for 60 mins
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Coagulation factor VII/tissue factor (CHEMBL2095194) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Structure-Based Design of Macrocyclic Coagulation Factor VIIa Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.73 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3594313 | — | — | 1 | 9.15 |
| CHEMBL3594314 | — | — | 1 | 8.80 |
| CHEMBL3594311 | — | — | 1 | 8.28 |
| CHEMBL3594315 | — | — | 1 | 8.10 |
| CHEMBL3594310 | — | — | 1 | 8.10 |
| CHEMBL3594312 | — | — | 1 | 7.52 |
| CHEMBL3594305 | — | — | 1 | 6.40 |
| CHEMBL3594304 | — | — | 1 | 6.04 |
| CHEMBL3594307 | — | — | 1 | 5.34 |
| CHEMBL3594302 | — | — | 1 | 5.34 |
| CHEMBL3594303 | — | — | 1 | 5.21 |
| CHEMBL3594309 | — | — | 1 | 5.00 |
| CHEMBL3594308 | — | — | 1 | 4.27 |
| CHEMBL3594306 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3594313 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL3594314 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL3594311 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL3594315 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL3594310 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL3594312 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL3594305 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL3594304 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL3594307 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL3594302 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL3594303 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL3594309 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL3594308 | — | Ki | = | 54000.0 | nM | 4.27 |
| CHEMBL3594306 | — | Ki | > | 18000.0 | nM | - |